CELL201 Lecture Notes - Lecture 8: Drug Detoxification, Cell Membrane, Carbohydrate Metabolism
Document Summary
Vesicular transport: components delivered from er to other compartments. Anterograde: movement of material towards plasma membrane. Retrograde: movement of material away from plasma membrane. Continuous network of flattened sacs, tubules and vesicles through the cytoplasm of eukaryotic cells. Rer: associated with ribosomes on the cytosolic side of the membrane. Transitional er: subdomain of rer helps in vesicle formation that travels from er to golgi. Cells that produce secretory proteins have more rer and cells that produce hormones have more ser. Assembly and budding of vesicles for transport. Drug detoxification: hydroxylation (addition of oh group) that makes the drug more soluble and easier to excrete. When exposed to drugs, amount of ser in the cells increase (proliferate) Glycoproteins and membrane lipids from er undergo further processing. A series of flattened membrane bound cisternae (3-8 cisternae make a golgi stack) Secretory cells have hundreds and thousands of golgi stacks and other cells might have just one.