CELL201 Lecture Notes - Lecture 9: Adp Ribosylation Factor, Ras Superfamily, Copii
13 Mar 2018
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Document Summary
Two methods of transport: exocytosis- animals secrete hormones, mucus, milk proteins, digestive enzymes; plant and fungi secrete enzymes and structural proteins for the cell wall. Polarised secretion: exocytosis of specific proteins is limited to a specific surface of the cell. Example: digestive enzymes only on the side of the cell that faces into the intestine: endocytosis. Phagocytosis: engulfing and digesting whole cells or microorganisms. Coated vesicles: layer of proteins cover vesicle surface called coat proteins. Coat proteins induce membrane curvature, participate in the collection of specific cargo molecules. Coats made of two multimeric proteins: clathrin and adaptor protein (ap) Triskelion- multimeric protein with 3 heavy chains and 3 light chains. Clathrin coats the vesicle and dynamin (a gtpase) binds to it. It is required constricting and closing the vesicle. As gtp is hydrolysed vesicle separated from the pm. Copi and copii vesicle coat assembly is initiated by members of ras superfamily of small.
