CAS NE 102 Lecture Notes - Lecture 10: Exocytosis, Endomembrane System, Nuclear Membrane
20 Jul 2016
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Document Summary
Vesicular transport: extends outward from the er to the plasma membrane, and inward from the plasma membrane to lysosomes. Proteins and lipids are transported along these pathways. Undergo various types of chemical modifications, such as the addition of carbohydrate side chains. Pic below: transport vesicles bud from one membrane and fuse with another, carrying membrane components and soluble proteins between compartments of the endomembrane system and the plasma membrane. Membranes maintain orientation (cytosolic side always faces cytosol) The extracellular space and each membrane-enclosed compartment (gray) communicate with one another by transport vesicles. Exocytosis: protein molecules are transported from the er, through the golgi, to the plasma membrane or to lysosomes. Endocytosis: extracellular molecules are ingested in vesicles derived from plasma membrane and delivered to early endosomes and onto lysosomes via late endosomes. Pic above: clathrin-coated vesicles transport selected cargo molecules. Coated vesicles: coats help to shape membrane into a bud and capture molecules for transport.
