CHEM564 Lecture Notes - Lecture 10: Fructose-Bisphosphate Aldolase, Antibody, Proteome
2 May 2017
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Some definitions: glycan: glycoconjugate: glycolipid: glycoprotein: glycoform: proteoglycan: mono- or oligo-saccharide structure mono- or oligo-saccaride modified protein or lipid glycan-modified lipid glycan-modified protein a glycoprotein isomer that differs only in its glycan structure heavily o-glycosylated proteins. There are three major classes of naturally occurring glycoconjugates: Lipid-linked glycan attached to a protein via a nitrogen atom (these are currently the best understood. ) glycan attached to a protein via an oxygen atom glycan attached to a lipid. N-linked glycans are some of the most common linkages in eukaryotic glycosylation. The name derives from linkage to an asparagine (asn, or n) residue. This linkage is part of the core" of the glycan structures. O-linked glycans are less common but are routinely found in eukaryotic systems. The o-link glycan tends to have more varied forms. The basic o-link is usually an 1- galnac: Bacterial systems from camplyobacter jejuni generate glycans very similar to mammalian n- linked glycans.
