GENET301 Lecture Notes - Lecture 5: Mitochondrial Biogenesis, Population Biology, Electron Transport Chain
23 Sep 2016
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Document Summary
Depends on the idea that the nucleus did not exist at the time that the symbiont was engulfed. Builds on the idea of co-evolution of mitos and nucleus. Speculation that invasion of introns from the endosymbiont to the host chromosome was a driving force to form a nuclear membrane. Group ii introns found in mt and chloroplast chromosomes. Mature spliced messenger rna that can be translated into a fuctional protein. Complex mechanism, inserts the intron sequence into dna, rt transcribes it into dna (acting like a mobile genetic element) So, in theory, the first option could allow spread of the intron throughout the genome. Why doesn"t this occur? (only about 30 copies/genome of alpha-proteobacterium) So, group ii introns spread to many locations in the host archaea dna. As they accumulate over time, some would naturally acquire mutations that destroy the maturase activity.
