IMIN200 Lecture Notes - Lecture 3: 51 Pegasi B, Cell Membrane, Glycoprotein

• School: University of Alberta
• Department: Immunology and Infection
• Course: IMIN200
• Professor: Mario Feldman

Document Summary

Imin200 lec3 viral entry is not a passive thing - getting into host membrane is the most dif cult thing for the membrane virus. Entry is part of the uncoding process - getting the nucleic acid out. Initium est dimidium facti. (once you(cid:2)ve started you(cid:2)re halfway there. ) Lots of glycoprotein - lots are receptors for viruses. Water on both sides and oil in the middle - need to pass thru oil layer to get into cell. Not easy to get in or out - energy requiring process. Plasma membrane showing integral and peripheral membrane proteins. Many proteins on the outside of cell are glycoproteins. Viruses cannot pass freely through membrane (in either direction). Many virus receptors are proteins (often glycoproteins) on the host cell to get things into the cell: Phagocytosis - take up particles surrounding the membrane. Pinocytosis - picking up solutes - not a common entry for viruses. Receptor mediated endocytosis - for most viruses of.