IMIN200 Lecture Notes - Lecture 1: Plasmodium, Mhc Class I, Malaria
3 May 2016
School
Department
Course
Professor
Document Summary
After studying lecture #10, you should be familiar with the following concepts: malaria. Malaria is a global health challenge that threatens 40% of the world population and causes 20% of childhood deaths in africa. Plasmodium parasites, of which the species falciparum is the most lethal. Plasmodium parasites are transmitted from one mammalian host to another by female mosquitoes: mosquito stage of life cycle. The female mosquito draws plasmodium gametes in a blood meal from an infected host. Gamete fertilization in the mosquito gut results in the formation of zygotes, which migrate to the gut epithelium and develop into oocysts. Sporozoites rupture from oocysts, migrate to salivary glands and are transmitted to a mammalian host as the female draws another blood meal. Salivary antigens can result in ige-based hypersensitive reactions in the host: liver stage of infection. Sporozoites rapidly shed their coats and migrate to the liver of their mammalian host.
