NEURO410 Lecture Notes - Lecture 25: Glial Fibrillary Acidic Protein, Oligodendrocyte Progenitor Cell, Neuromyelitis Optica
12 Oct 2016
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Lecture 14: glial cells and neurological diseases (april 6/16) Objectives: glial cell types and their ontogeny, diseases of glia. T and b cells, neutrophils and macrophages can traffic into brain with relatively fixed pattern. Microglia = derived from yolk sac early in development and only later that they come into the nervous system. Astrocytes = live longer than microglia (but they still undergo turnover) Immense communication b/w diff microglia cell types and that b/w microglia and neurons to defense, then. From common progenitor cells neuronal and glial progenitor cells. Can take neuronal progenitor cells and differentiate (with trophic factor admin) Note: no microglia here (diff route; from neural yolk sac; recall) into diff types. Most abundant cell type in the cns; species dependent (ie 90% of mouse brain = astrocytes) Type i and ii astrocytes; also fibrillary, protoplasmic and radial types (specific terms; not driven by molecular markers); old fashioned descriptor terms.
