NEURO410 Lecture Notes - Lecture 10: Ciliary Neurotrophic Factor, Brain-Derived Neurotrophic Factor, Glial Cell Line-Derived Neurotrophic Factor
12 Oct 2016
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Lecture 10 b: neurotrophic factors for treatment of ndd (feb. 3/16) Ndd are characterized by death of specific neuronal populations. Strategy: use neurotrophic factors (ntfs) to protect neurons and achieve neurorestoration. Neurotrophic factors (ntfs) are secreted small proteins that regulate the nervous system: They regulate one or more of the 3 main processes: Binds to receptors expressed on surface of responsive cells and activate signaling mechanisms. Nft have to be able to take signal outside of neuron and bring it into neuron. R needs to be tm to transmit signal. Two rs: homodimer and heterodimer (only 1 part tm) Phosphorylation series of biochemical reactions (phosphorylation most important) different changes in neurons (3 ways listed in image; 2 and 3 are not transcriptional) (image): ntf or different families interact with r; are many different rs (even for ngf have two different types of r); understanding how ngf interacts with trka (pro-survival) and p75 (pro-death) = important implications for ndd.
