PEDS200 Lecture : Cardiovascular System
Document Summary
Increase in blood shunt to working muscles (less blood shunted to non-working, non-essentail y. Increase in systolic bp and only a slight change in diastolic bp tissues) y y. Increase in pre-load due to increase in blood flow returning to heart and muscle pump action of working muscles. Increase in respiratory pump action of inspiration and expiration and some veno-constriction which reduces pooling in the extremities. Fick equation (vo2) = o2 transport x o2 utilization y. Peripheral factors y o2 extraction (diffusion into the muscle) y capillarization (number of capillaries around each muscle fiber) y myoglobin concentration (this is controversial) y oxidative capacity of muscle y gender higher in men than women. At rest: y cardiac hypertrophy (an increase in cavity size of ventricle and possible an increase in wall thickness) y decrease in resting hr, due to a decrease in in sympathetic and an increase in ps drive y.