PHYSL210A Lecture 2: Components of the nervous system
22 Oct 2018
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Cortical pyramidal neurone: pyramid shaped soma surrounded by an array of basal dendrites. Apical dendrites: located distant from the soma, close to the cortex. Purkinje neurone: in the cerebellum, have a flat fan like dendritic tree: cell membrane structure. Most plasma membrane proteins have subunits and have a quaternary structure. Primary structure (chain of amino acids) secondary structure (helix or sheet) tertiary structure quaternary structure: voltage gated sodium channels. Responsible for the generation of action potential. Four subunits form a selectivity filter at the extracellular face of the protein. Selectivity filter is negatively charged so it only allows na ions, small cations but not anions. Inner mouth of the channel has voltage sensors (proteins), when the membrane potential is depolarised a conformational change in the channel allows na ions in the cell. There is intracellular gate which needs to open for flux: diffusion. Molecules move from higher concentration to lower concentration.
