PHYSL210A Lecture Notes - Lecture 15: Blood Transfusion, Fibrin, Factor 5
1 May 2019
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Document Summary
Physiological mechanism of blood clotting in vivo: inside our body, blood clotting is initiated by the extrinsic pathway: rupture of a blood vessel cause cells around it releases chemicals called tissue factor. Activates factor 7 activation of factor 10. Very tiny amount of thrombin, thrombin can activate factor 11 to 11a and activate factor. Factor 12 is not needed in vivo for blood clots. In vitro factor 12 is needed for blood clot. Deficiency of factor 7: patient bleeds severely no initiation of the cascade pathway for blood clot. Deficiency of factor 8: factor 10 not converted to factor 10a, deadly, blood transfusion. Deficiency of factor 11: not calling upon the whole sequence as all the other factors 7, 9 and 11, moderately bleeding patient. Thrombin: small amount causes activation of more platelets on that site; converts fibrinogen to fibrin; activation of other clotting factors and co-factors; activation of protein "c" not related to blood coagulation but anti-coagulant activity.
