PHYSL210B Lecture Notes - Lecture 15: Chronic Kidney Disease, Bone Resorption, Thyroid
3 Apr 2019
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Document Summary
Bones are a storage site for calcium. It has an organic component that gives flexibility and it has inorganic component that gives strength. Osteoblasts bone deposition; addition of ca2+ to bone by laying down organic component first and then hydroxyapatite can be laid down. Osteoclasts bone resorption; release of ca2+ from bone into the blood by released acid and enzymes to break down calcified material. When ca levels are high osteoblasts activity increases; when ca levels are low osteoclast activity increases. Target sites bones, kidneys and digestive tract. Location: at the black of the thyroid gland. Pth is secreted by parathyroid glands in response to low blood plasma. Pth is a peptide hormone (hydrophilic) that acts on receptors on the cell membrane of a cell. It stimulates bone resorption so that calcium can be released into the blood stream. It can also act on kidneys by increasing calcium reabsorption.
