PHYSL402 Lecture Notes - Lecture 8: Amylin, Beta Cell, Glycogen Synthase
13 Oct 2016
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Describe how glucose regulates insulin secretion at multi levels and the importance of glucose metabolism in beta-cells. Describe the nutrient, hormonal and nervous regulation of insulin secretion. List the effects of insulin that lead to lowering of blood glucose. (review specific metabolic pathways/enzymes regulated by insulin in liver, muscle and adipose tissue): not covered today. Describe how activation of the insulin receptor is involved in protein synthesis and aging. In meal eating animals, circulating nutrient [ ]s fluctuate widely over 24 hr. Hormones control nutrient metabolism to ensure a constant e supply to brain. Insulin is the major regulator of post-meal metabolism. First to present that pancreatic extracts can be injected into pt. Insulin = major regulator; interesting that is no redundancy. T1d used to be deadly, as your cells essentially (cid:862)star(cid:448)ed(cid:863) to death e(cid:448)e(cid:374) (cid:449)ith food i(cid:374)take. T2d: insulin also important (top): measure blood sugar; our ability to deal with postmeal glucose = first problem (elevation)
