PHYSL402 Lecture Notes - Lecture 7: Cortisol, Homeostasis, Pyruvic Acid

• School: University of Alberta
• Department: Physiology
• Course: PHYSL402
• Professor: Dr.shamza

Document Summary

Lecture 7: skeletal muscle and lipid in glucose homeostasis: jan. 18/16. Key role in insulin resistance: thought to be a primary player. Largest organ, major site of insulin-stimulated glucose uptake (post-prandial): accounts for. Foundation for physical activity and fitness (fitness of internal enviro: maintain homeostasis) Key: maintain insulin production (endogenous pancreas production) and target tissue sensitivity. Insulin can increase skeletal muscle glucose extraction by >10x. Recruitment of glut4 and modulation of intracellular enzymes for glycogen synthesis and glucose oxidation: insulin = doing similar things here as other tissues. G-6-p mediated gradient: phosphorylation of gluc steep glucose gradient. (cid:373)e(cid:373)(cid:271)ra(cid:374)e glu(cid:272)ose tra(cid:374)sport is rate li(cid:373)iti(cid:374)g, but i(cid:374)suli(cid:374)"s intracellular effects sustain rapid glucose influx. Do(cid:374)"t (cid:373)e(cid:373)orize the (cid:373)ediators; appre(cid:272)iate sig(cid:374)ali(cid:374)g i(cid:374) skeletal and mediation of gluc transport = very difficult. Do know that insulin, when bound to r, leads to chain of events that leads to translocation of glut4 to cell membrane, mediating gluc transport into cell.