PHYSL402 Lecture Notes - Lecture 24: Cardiac Skeleton, Cardiac Output, Perfusion
7 Nov 2016
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Document Summary
Accumulation of fat that presents a risk to health. When energy intake > energy output, you get fat storage. Affects all areas of body, but focus on cv aspects (hypertension) Altered metabolic profile, adaptations/alterations in cardiac structure & function. Grows the most and progressively grows if obesity is not stable. Adipocytes are close to capillary network with high permeability --> good exchange. Resting blood flow to adipose --> 10x: but less than for skeletal muscle which can increase by 50x. Tissue flow increases after meals, but this is variable and can be decreased in obese patients with metabolic syndrome: this is not linear. Perfusion per unit of adipose tissue actually decreases with increasing obesity: 35% reduction. Increase in lean body mass in obese patients accounts for some increased co: note: they are still mobile, so it"s like resistance training. Increase in co and increased bv is partially caused by increased metabolic demand induced by excess body weight.
