PMCOL305 Lecture Notes - Lecture 10: Flunitrazepam, Chlordiazepoxide, Alfentanil
Document Summary
Understand the behavioural and physiological effects of benzodiazepines and what happens during withdrawal. Be able to id the structural features of a benzodiazepine. Learn about ghb and its effects on the cns. All increase effects of gaba in the cns and generally depress neuronal excitability (with some exceptions) All are used clinically to some degree, including ghb (used to treat narcolepsy) Are 5 subunits per r with multiple alpha, beta, and gamma subunits (1-3) available: usually have 2 alpha, 2 beta and 1 gamma. Benzodiazepine binding site is separate from the gaba binding site. Benzodiazepines librium (the 1st marketed benzodiazepine) xanax, valium, ativan. 2 binding sites for gaba; only one for benzos. Formed b/w alpha (except 4 and 6) and gamma subunits. They increase the affinity of the r for gaba and increase the freq of channel opening (allosteric effect) Allosteric effect: when one has a distance effect on another. Benzodiazepines only exert effects if gaba binds also they can.