STAT151 Lecture Notes - Lecture 13: Allele Frequency, Genetic Drift, Population Genetics

• School: University of Alberta
• Department: Statistics
• Course: STAT151
• Professor: Gregory Wagner

Document Summary

Total individuals p= 2(aa) + 1(aa) / 2(total individuals) q= 2(aa) + 1(aa) / 2(total individuals) p= 2(1125) + 1(750) / 2(2000) p = 0. 75 q=2(125) + 1 (750) / 2(2000) q=0. 25: note !!! Knowing allele frequencies alone does not tell you anything about the population structure, or fitness advantage/disadvantage of various alleles e. g. each of these populations each has p=0. 8, q=0. 2. Hw formula can be derived from simple probability (punnet square) p2= frequency of aa genotype. 2pq = frequency of aa genotype q2= frequency of aa genotype. Use hw formula with observed allelic frequencies as inputs to calculate expected genotypic frequencies as outputs. = 1125 aa individuals in a population of 2000. = 125 aa individuals in a population of 2000. = 750 aa individuals in a population of 2000 e. g. if p=0. 75, q=0. 25. Note that in this case, the expected genotypic ratios matched the observed genotypic ratios; this population is in hardy-weinberg equilibrium .