ZOOL344 Lecture Notes - Lecture 6: Substantia Nigra, Hemocyanin, Protoporphyrin Ix
15 Nov 2017
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These all have a protein backbone, and a metallic ion (fe or cu) core: all these proteins bind to o2 reversibly (i. e. , both bind and release) and rapidly (10 msec). Lobster ones are directly in the plasma: [do you really need it?] It consists of ferrous hexahydrate and protoporphyrin components. Therefore, carbon monoxide poisoning can occur even at very high o2 partial pressures. (competitive inhibition: other competitive inhibitors for o2 binding at the heme site includes cyanide. So, a very little drop in partial pressure will release a lot of oxygen at the tissues. Check omg waaaat: no transfer of blood to the fetal circulation, beta chains develop prior to birth and rapidly replaces all the other types of chains by age 3, temperature. Water vapour saturation can correct for the partial pressure due to knowing water vapour is 100% saturated.
