CMMB 421 Lecture Notes - Lecture 18: Picornavirus, Flaviviridae, Flavivirus
Document Summary
First disease in which they were studied was yellow fever. Has a capsid, single +rna genome, with lots of secondary structure, as well as membrane proteins associated with envelope. Protein e: folds flat over surface of mature virion. Very similar to picornavirus because if we look at how genome is organized, see it has a polyprotein that is processed to give proteins involved in virus assemble. Complicated than picornavirus because need to make membrane protein first. Clustering of genes is similar to picornavirus because structural genes are at 5" end and non structural genes are 3" end of genome. As proteins are translated, they have to fold into the internal membrane of the infected cell. This happens so fast that the polyprotein exists in theory, it is processed very fast. Some of the proteins involved in cytoplasmic events stay on cytoplasmic side of golgi or otherwise in lumen. Less prevalent now, but we do have a vaccine.