CMMB 421 Lecture Notes - Lecture 7: Phage Therapy, Ribosome-Binding Site, Dna Virus
28 Dec 2019
School
Course
Professor
Document Summary
Phages initially attracted attention because of application in phage therapy, then became important tools and model systems in molecular biology; now regaining interest due to applications. Phages mostly have ds dna genomes, but some exist with ssdna, ssrna(+), and dsrna (baltimore groups 1,2,3,4) Family of small icosahedral viruses with ssrna (+) genomes (baltimore group 4) Levi = light, because they are small viruses. Coat protein, rna genome, a protein (important in attaching to receptor and delivering genome into host) Depending on genera, there is slightly different conformation of what is encoded. Protein a is important in attaching the phage to the host cell"s receptors and delivering genome. Rna is single stranded with lots of secondary structure creating double stranded regions. Problem in terms of replicating virus because we need different abundances of different proteins. With dna viruses this is easy to solve because you have different promoters on different genes that are expressed at different levels.
