RELS 200 Lecture Notes - Lecture 2: Embryonic Stem Cell, Inner Cell Mass, Somatic Cell Nuclear Transfer
Document Summary
Lecture 2 cell proliferation, tissue renewal and stem cells. Cells can be reprogrammed to stem cell for tissue has a tissue specific repair and maintenance the embryo is totipotent embryonic stem cell is pluripotent tissue specific stem cell is multi-potent. Blastocyst early stage embryonic developme inner cell mass conta es cells. Embryonic stem cells: eunucleated egg a+nucleus b, develop to blastocyst. Stem cell therapy: neurodegenerative disease e. g. - parkinson"s a replace dopamine producing cells, repair muscles. E. g. -duchenne"s muscular dystrophy: diabetesa have pancreatic beta cell replacement, spinal injuries, heart repair, leukemia, cure progressive blindness. Stem cells are undifferentiated cells that are capable of : self-renewal a production of another stem cell, commitmenta production of cells that are committed to differentiate. Only stem cells give rise to stem cells. Stay as stem cells or produce stem cells that specialize. As differentiation proceeds, cells lose the ability to produce different cell types. Zygote can form whole embryo and extra embryonic tissues.