ANSC 4650 Lecture Notes - Lecture 11: Immunoglobulin Class Switching, Memory B Cell, Antigen Presentation

• School: University of Guelph
• Department: Animal Science
• Course: ANSC 4650
• Professor: Niel Karrow

Document Summary

Involved in keeping the peripheral tolerance of t and b cells to self antigens as well as commensal micorbes: lcs trap epidermal antigens. Il-10, tgf-b, pge2 and histamine: the thymic pdcs have an immature phenotype so can not give signals 2 and. 3 (costimualtory and cytokine receptor mediated) to thymic t cells: mechanism by which pdcs and other dcs are able to steer the differnetation of regulatory t cell populations. Assembly of mhc class ii molecules: non classical mhc class ii molecule dm mediates clip exchange for antigenic peptide, do regulates dm activity. Endogenous antigen processing and presentation: the machinery for processing intracellular micorbes and presenting endogenous antigens to tc-cells is different and needs mhc class i molecules. In some instances, exogenous viral proteins may not be fully degraded in the phagoendosome and may be moved to the cytoplasm: it is then processed by proteasome.