ANSC 4470 Lecture Notes - Lecture 24: Citric Acid Cycle, Transaminase, Glutamine
8 Apr 2016
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Orange on diagram is the nitrogen movement, blue shows the carbon movement. Transaminaion reacion, puts amino group on other compound. Alanine becomes pyruvate by losing its amino group, -kg takes the amino group and becomes glutamate. Deaminaion: glu -kg + nh4, gln glu + nh4, asn asp + nh4. Urea is water soluble, no impact on neural transmission, etc: no enzymes that use urea excreted with water, h+ ions produced, bind to bicarbonate (hco3. Ornithine and arginine loat in blood, no trnas for them, do not end up in proteins but they are amino acids: citrulline and arginino-succinate are also amino acids. Fumarate comes of, part of the tca cycle. The gut is like a mini-carnivore in the body, breaks down amino acids for fuel, even in herbivores, to generate atp: use glutamine primarily, glutamate can transaminase on pyruvate to make alanine.
