ANSC 4650 Lecture Notes - Lecture 8: Chemerin, Cell Adhesion Molecule, Icam2

• School: University of Guelph
• Department: Animal Science
• Course: ANSC 4650
• Professor: Niel Karrow

Document Summary

Macrophage subpopulations: similar to neutrophils, macropahges use oxidative and non oxidative killing mechanism, can also use neutrophil granular contents, m1 inflammatory macrophages, make inducible nitric oxide synthase (inos2) which uses nadph and. Il-10 producing macrophages: e coli 0157:h7, compete commensals by using n2 instead of o2 for metabolism, h pylori, capacity to detoxify no. Macrophage regulatory functions: act as antigen presenting cells. Il-1, il-6) and steer the acquired immune response: th1 cell steering il-12, il-18, th2 cell steering il-1, il-6, il-10, il-13, th17 cell steering tnf-a, il-6, il-23, regulatory t cell steering tgf-b, il-10. Pathways of macrophage activation and polarization: can be activated by pamps/alarmins, become pro-inflammatory m1 effector macrophages, secrete tnf-a and il-12, activates innate nk cells to make ifn-y, also made by neutrophils and (cid:576)(cid:577)-t cells. Ifn-y: activates m1 macrophages to a higher level of activation and induces nos2 gene transcription during the acquired immune response, come mainly from th-1 cells.