BIOC 3560 Lecture Notes - Lecture 7: Dissociation Constant, Hemoglobin, Fetus
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25 Nov 2014
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Changes in amount of bpg (adaptive response) in the body will alter the way hb binds to oxygen thus satisfying the oxygen demand. Bpg plays a role in the transfer of oxygen from maternal blood to fetal blood. Adult hemoglobin is different than the one present in the fetus. The fetal form (gamma) has a lower affinity for. Bpg therefore the kd for bpg is higher than hb adult. At a given level of bpg hb gamma will bind to less bpg. This gives it an increased affinity for oxygen. Remember that bpg was a negative allosteric modulator. If you were to draw a curve of fetal hb on top of a curve with bpg the curve will be shifted to the. We express the gamma gene until birth then the expression stops and the beta form is produced. So once you are born you switch to beta hb.
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