BIOC 4580 Lecture Notes - Lecture 25: Membrane Potential, Nuclear Membrane, Pathogenic Bacteria
14 Mar 2017
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Document Summary
Whereas lipid biosynthesis occurs on the smooth er, membrane protein biosynthesis occurs on the rough er. Membrane proteins, as well as proteins destined for secretion or specialized organelles, have. Integral membrane proteins have additional internal start & stop anchor sequences that help define their topology. Bioinformatics (hydrophobicity) analyses allow us to predict these topological determinants. Gpi-anchored proteins are also synthesized on the rer. Bacterial translocation systems are analogous to those in eukaryotes. Membrane protein biogenesis in eukaryotes mrna + ribosome protein. Membrane protein synthesis in eukaryotes involves protein trafficking through a series of. Free cytosolic ribosomes synthesize soluble proteins destined for the cytosol or nucleus. Membrane-bound ribosomes (on cytosolic surface of er rough er) synthesize integral, secreted, & lysosomal proteins. Proteins are co-translationally inserted into er membrane, or translocated into er lumen. Proteins then move outwards from er, through golgi, to plasma membrane. Sphingosine lipids starts to get synthesized in ser with final processing in gc.
