BIOL 1090 Lecture Notes - Lecture 27: C-Terminus, Clathrin, Lipofuscin
18 Jan 2017
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Document Summary
Amino acid sequence directs proteins back to er = er retrieval signal. Kdel receptors in membranes of cgn and cis-golgi bind to retrieval signal of escaped proteins. Kdel receptors bind to copi complex proteins and are incorporated into copi vesicles. Made of 3 heavy and 3 light chains. Triskeletons interact to form polyhedral lattice, a basket-like structure surrounding vesicle. Ccv: adaptor proteins between clathrin lattice and the cytosolic face of the vesicle. Selectively sot cargo at tgn, cell membrane and endosomal compartments. Lysosomal membrane: glycosylated proteins: protected lining next to lumen. Tonoplast= vacuolar membrane which contains active transport systems that generate high interior [ion] Intracellular digestion ~lysosome: low ph, acid hydrolases. Storage: solutes and macromolecules, toxic compounds. Harmful by-products of cellular metabolism (no excretory system) Mechanical support, turgor pressure: support to soft tissue cells, stretches cell wall during growth. Exocytosis involves fusion of secretory vesicles with pm followed by discharge of vesicle contents.
