BIOL 1090 Lecture Notes - Lecture 6: Cytoskeleton, Clathrin, Tethering
28 Mar 2017
School
Department
Course
Professor
Document Summary
A single golgi body (golgi comlex ; apparatus) Proteins are modified step-wise as they transverse the golgi. Different cisternae of the golgi contain different enzymes that modify proteins. The differential staining of the golgi cisternae reflects their biochemical differences. Smooth, flattened, disk like cisternae (~0. 5 1 micron in diameter) 8 (or fewer) cisternae/stack (range from a few to several 1000 stacks per cell) Shows polarity: cis medial trans cisternae, cisternae are biochemically unique. Membrane supported by protein skeleton (actin, spectrin) Scaffold linked to motor proteins that direct movement of vesicles into and out of the golgi. Modification of proteins and lipids: glycosylation (glycoproteins & glycolipids, proteolytic modification. N-linked oligosaccharides: synthesis begins in the er. Proteins with n-linked oligosaccharides arrive from er. O-linked oligosaccharides: synthesis/modification entirely in golgi. Cgn acts as a sorting region : sorts whether proteins should continue on to the next. Golgi station or be shipped back to er.
