BIOL 1090 Lecture Notes - Lecture 22: Hydrolysis, Sarcoma, Guanine
8 Apr 2016
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Nuclear envelope: nuclear membrane, nuclear lamina, nuclear pores. Nuclear content: chromain, nucleoplasm, nuclear matrix, nucleolus. Outer membrane binds ribosomes and is coninuous with rough er (rer) Inner membrane contains integral membrane proteins that connect to nuclear lamina. Separates nuclear content from cytoplasm: separates transcripion and translaion. Selecive barrier: allows limited movement of molecules between nucleus and cytoplasm. Integrity regulated by phosphorylaion: bound to inner surface of nuclear envelope (ne) Via prenyl group linked to lamin polypepide. Funcion: support structure for ne, atachment sites for chromain. Mutaions in a lamin gene (lmna) implicated in hutchinson-gilford progeria syndrome, a rare disease that causes premature aging in children. Nuclear funcion is dependent upon protein import: structural proteins. Dna packaging: dna replicaion, dna repair, transcripion, rna processing and export, ribosome synthesis and export. Inner and outer membranes of ne fuse at pores: approx. Gateways between cytoplasm and nucleoplasm: 3000-4000 pores/nucleus, facilitate nucleo-cytoplasmic transport. Protein structure ills nuclear pore: supramolecular complex.
