BIOM 3090 Lecture Notes - Lecture 20: Antipsychotic, Dopamine Receptor, Autopsy

• School: University of Guelph
• Department: Biomedical Sciences
• Course: BIOM 3090
• Professor: Bettina Kalisch

Document Summary

Psychosis and the dopamine hypothesis: 1, antipsychotics blocks d2 receptors, 2. Drugs that increase dopamine activity aggravate or produce psychosis: 3. Increase dopamine receptor density in schizophrenic patients: 4. Decrease dopamine metabolites in successfully treated schizophrenic patients: decrease in dopamine transmission. Dopamine pathways: three main da pathways, 1. Mesolimbic associated with behaviour: increased dopamine transmutation in limbic system linked with positive symptoms, decreased dopamine transmission in cortex linked with negative symptoms. Gaba neuron now stimuliaing gaba neuron have more gaba released to bind to gaba receptors (inhibitory) so when gaba binds to receptors on dopamine neurone it decreased release of dopamine. If block 5ht2a receptor (upper left) will decrease stimulation of dopamine neuron and decrease dopamine release - prevents serotonin from activating gaba neuron so increase dopamine release. Nmda receptor: drugs that increase glycine levels or bind to glycine modulatory site of nmda receptor under investigation.