BIOM 3200 Lecture Notes - Lecture 2: Corticotropin-Releasing Hormone, Anterior Pituitary, Paraventricular Nucleus Of Hypothalamus
10 Feb 2018
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Hypothalamus anterior pituitary adrenal cortex axis: hypothalamus, anterior pituitary, goes through blood stream to go to adrenal cortex, adrenal cortex. Crh: corticotropin releasing hormone (brain hormone from the hypothalamus) Cortisol: glucocorticoid, chronic stress hormone (long term stress, not same as fight or flight. Inhibitory influences: physiological levels of cortisol inhibit release of crh (and possibly inhibit pre-propcrh gene expression) Hypothalamus is one mall, but different parts are different stores. Pomc family (peptides: acth: adrenocorticotropic hormone, regulates adrenal cortex function. Convertases: enzymes that cleave pomc, different convertases give rise to different products. Adrenal gland, like pituitary gland = 2 embryological distinct tissues merged during development. Adrenal cortex = steroid factory: glucocorticoids (e. g cortisol, mineralocorticoids (e. g. Adrenal medulla = modified sympathetic ganglia secrete catecholamines: catecholamines, epinephrine. These are secreted by different regions of the adrenal cortex. Cholesterol pregnenolone 17oh-pregnenolone 17oh- progesterone 11- ** steps to make cortisol: both pregnenolone and cortisol are enzymes of the inner mitochondria.
