BIOM 4090 Lecture Notes - Lecture 2: Exemestane, Ethinyl Estradiol, Dehydroepiandrosterone

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Gonadal axis, posterior pituitary, and bone mineral homeostasis. In males, testosterone inhibits gonadotropins (via negative feedback) In females, estrogen can exert both inhibitory and excitatory effects on gonadotropins (depending on the rate of change and the absolute concentration of estrogen, as well as the stage of the menstrual cycle) Continuous stimulation and release of gnrh yields gnrh receptor down-regulation . Inhibin, which is a hormone produced by the sertoli cells of the testes and granulosa cells of the developing follicles, inhibits further fsh release with little effect on lh secretion. Activin is a paracrine factor that is produced and acts locally both in the pituitary and in the gonads, and functions in the pituitary gland to stimulate primarily fsh secretion. Fsh and lh: are structurally similar glycoproteins that bind to surface receptors on the cells of the ovaries and testes upon release. In the ovary, fsh stimulates follicular development while lh stimulates ovulation.

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