BIOM 3200 Lecture Notes - Lecture 5: Endoplasmic Reticulum, Coagulation, Hydroxylapatite

• School: University of Guelph
• Department: Biomedical Sciences
• Course: BIOM 3200
• Professor: Tami Martino

Document Summary

Calcium background: calcium salts (with phosphate) provide the structural integrity of bone. Intracellular and extracellular calcium ions are essential for several normal biochemical processes: neuromuscular excitation, blood coagulation, hormone secretion, enzyme activity, fertilization. 1,200g ca2: 99% of ca2+ is in your bones. Stably stored as hydroxyapatite: soft tissues intracellular 11g, extracellular 1 g. Extracellular ca2+ is very tightly regulated io(cid:374)ized calciu(cid:373) (cid:894)(cid:862)free(cid:863); 50%(cid:895: protein-bound calcium (40%, calcium complexed with phosphate and citrate (10%) Cellular ca2+ is also highly regulated largely associated with membranes in mitochondria, endoplasmic reticulum and plasma membrane. Parathyroid can not- essential for lie: parathyroids seen in terrestrial amphibians onwards, 2 cell types: chief cells (produce pth) and oxyphils (function unknown, homogeneous tissues. Parathyroid hormone (pth: peptide produced by the parathyroid gland, when plasma ca2+ begins to fall, pth acts to raise blood ca2+ back to normal levels.