MBG 3060 Lecture Notes - Lecture 4: Harriet Creighton, Linkage Disequilibrium, Cytogenetics

• School: University of Guelph
• Department: Molecular Biology and Genetics
• Course: MBG 3060
• Professor: Andy Robinson

Document Summary

Autosomal linkage: two or more loci on the same autosome or created by selection (by identifying alleles we prefer over ones we don"t) or inbreeding (artificially creating homozygosity) B more random assortment of gametes passed on together over time possibility for recombination relatively tight linkage, well connected. Who first described linkage: credited to a. h. sturtevant. Worked on inheritance of coat colour in horses. Constructed the first map of a chromosome in 1913 as part of his ph. d. thesis. Explained recombination in the paper from his thesis. P: harriet creighton and barbara mcclintock, 1931, demonstrated cytogenetic and phenotypic evidence using corn demonstrated linkage important for genomic selection methods - identify markers for genome we want and knowing the loci in those regions. Geo-political references: balkan powder keg was brewing. Start of events leading to ww i: romanov"s still in power in russia, suffragette movement, henry ford started assembly line for model t, first home refrigerator ( u. s. )