MICR 2420 Lecture 4: MICR 2420 Lecture 4

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What is an archaea?
These microbes (archaea; singular archaeon) are prokaryotes, they have no cell nucleus
or any other membrane-bound organelles in their cells
Archaea is derived from the Greek word archaios, meaning “ancient” or “primitive”
Despite the morphological similarity to bacteria, archaea possess genes and several
metabolic pathways that are more closely related to those of eukaryotes, notably the
enzymes involved in transcription and translation
Archaea have more complex RNA polymerases than Bacteria, similar to Eucarya
Unlike bacteria, archaea cell walls do not contain peptidoglycan
Archaea have different membrane lipid bonding from bacteria and eukarya.
Archaea found in soil and water habitats in symbiosis with plants and animals and in
extreme environments
No Archaea is yet to known to cause diseases, but archaea do interact with our innate
immune system
Archaea look like bacteria but are NOT bacteria
They are as closely related to bacteria as we are!
Although they can be found in many different environments, many species live under
extreme conditions
Overall, they grow within a wider range of temperature and other environmental
conditions than either bacteria or eukaryotes
Archaeal cell membrane traits
Cell membranes very different from bacteria & eukaryotes
Archaea use L-glycerol linked to side chains using ether links
Bacteria use D-glycerol linked to side chains using ester links
oEther links are much more stable than ester links
oL- and D-forms of glycerol have similar properties but require completely
different sets of enzymes for synthesis
Isoprene subunits link together to form isoprenoid (imparts membrane stability)
-Overall lipid is diphytanylglycerol diether
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In some extremophiles, the ends of the side chains link up covalently with each other or
to other lipids, or even form a cyclic structure
Strengthens the membrane considerably
Allows some of the more weird Archaeal shapes(e.g.squares!)
Two pairs of lipid chains cross linked across the membrane form a tetraether
Archaeal lipids lack the fatty acids found inBacteria and Eukaryotes and instead have
side chains composed of repeating units of isoprene
In some Archaea, the lipid’s methyl branches cyclize, forming cyclopentane rings
oCyclopentane rings strengthen membranes at high temperature
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Archaeal cell wall
The cell wall of some methanogens is actually very similar to that of bacteria
Instead of peptidoglycan, a molecule, pseudopeptidoglycan (pseudomurein) is used
oInstead of N-acetyl muramic acid, there is N-acetylalosaminuronic acid
• Pseudopeptidoglycan is not affected by either lysozyme or penicillin
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Document Summary

These microbes (archaea; singular archaeon) are prokaryotes, they have no cell nucleus or any other membrane-bound organelles in their cells. Archaea is derived from the greek word archaios, meaning ancient or primitive . Despite the morphological similarity to bacteria, archaea possess genes and several metabolic pathways that are more closely related to those of eukaryotes, notably the enzymes involved in transcription and translation. Archaea have more complex rna polymerases than bacteria, similar to eucarya. Unlike bacteria, archaea cell walls do not contain peptidoglycan. Archaea have different membrane lipid bonding from bacteria and eukarya. Archaea found in soil and water habitats in symbiosis with plants and animals and in extreme environments. No archaea is yet to known to cause diseases, but archaea do interact with our innate immune system. Archaea look like bacteria but are not bacteria. They are as closely related to bacteria as we are!

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