MICR 2420 Lecture Notes - Lecture 15: Quorum Sensing, Euprymna Scolopes, Homoserine
27 Jun 2018
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ckhursig@uoguelph.ca
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Document Summary
A discovery that fundamentally changed the way we think about microbes was made during studies of aliivibrio fischeri, a peculiar marine microorganism that colonizes the light organ of the hawaii an bobtailed squid (euprymna scolopes) Induction of a quorum-sensing gene system requires the accumulation of a secreted small molecule called an autoinducer. At a certain extracellular concentration, the secreted autoinducer reenters cells. It binds to a regulatory molecule, which in the case of allivibrio fischeri is. The luxr-autoinducer complex then activates transcription of the luciferase target genes that confer bioluminescence. Many pathogens use quorum sensing to control virulence genes. Its virulence proteins include proteases and other degradative enzymes. These are not produced until cell density is fairly high, and can overwhelm its host. Some microbial species use quorum sensing to communicate with other species. One of the most fascinating results of evolution is how organisms adapt to the presence of others.
