MICR 2420 Lecture Notes - Lecture 21: The Lancet, Enterotoxigenic Escherichia Coli, Pentamer

• School: University of Guelph
• Department: Microbiology
• Course: MICR 2420
• Professor: Lucy Mutharia

Document Summary

E. coli: phylum: proteobacteria, family: enterobacteriaceae, gram negative, facultative anaerobe, most strains are motile using flagella, not all e. coli strains are bad! However, e. coli 0157:h7 is a notorious pathogen classified as an enterohemorrhagic e. coli (ehec) History: first description of e. coli o157:h7. Linked to undercooked hamburgers at a fast food chain (hamburger disease: other sources identified over time, now a major problem. There are over 700 antigenic types of e. coli. Serotyping is done to distinguish which ones are associated with disease. E. coli serotypes that cause hemorrhagic disease: also (cid:373)ight see a (cid:858)k(cid:859) (cid:374)u(cid:373)ber, relates to capsular antigen. 157th somatic o antigen 7th flagellar h antigen: coli o157 emergence. Large western states outbreak, 500 cases and 4 deaths. Walkerton, ont: may 2000, e. coli 0157:h7 contaminated the water supply for the town, contaminated farm run-off entered groundwater reservoirs and wells. Criminal negligence by municipal water utilities management, and falsification of water testing documents: thousands sickened, 7 people died.