MICR 2420 Lecture 23: MICR 2420 Lecture 23

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27 Jun 2018

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Examples of Pathogen

Human immunodeficiency virus

(HIV)

Joan L. Slonczewski and John W. Foster

Microbiology:

An Evolving Science

FOURTH EDITION

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Human Immunodeficiency Virus (HIV)

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The Human Immunodeficiency Virus or HIV virus as it is

commonly known is a unique type of virus (a retrovirus). The

human immunodeficiency virus is a lentivirus that causes the

acquired immunodeficiency syndrome, a condition in humans

in which progressive failure of the immune system allows

life-threatening opportunistic infections and cancers to thrive.

What is HIV

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Document Summary

The human immunodeficiency virus or hiv virus as it is commonly known is a unique type of virus (a retrovirus). The human immunodeficiency virus is a lentivirus that causes the acquired immunodeficiency syndrome, a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive. Recall the biological origin of hiv and the history of its discovery. Summarize the hiv cycle, including attachment, host cell entry, genome replication and integration, and virion assembly and exit. Distinguish hiv drugs based on their molecular target. 26. 5 define the four stages of hiv infection. 19. 5 million people were accessing antiretroviral therapy in 2016. 36. 7 million [30. 8 million 42. 9 million] people globally were living with hiv in 2016. 1. 8 million [1. 6 million 2. 1 million] people became newly infected with hiv in 2016. 1 million [830 000 1. 2 million] people died from aids-related illnesses in 2016.

Related Questions

3. The standard blood test screen for the Human Immunodeficiency Virus (HIV) detects antibodies to the virus using a laboratory test known as ELISA (enzyme-linked immunosorbent assay). If the ELISA test is run properly under recommended conditions, it has a sensitivity of 99% and a specificity of 99%.

a) (4 pts) Assume the HIV-ELISA test is administered to a low-risk community of 100,000 people. By low-risk we mean a population which has an HIV prevalence of 1%. Construct the appropriate 2 X 2 table, determine the number of false positives and false negatives, and calculate the positive predictive value of the ELISA test in this population.

b) (4 pts) Assume the same ELISA test with the same sensitivity and specificity is used to screen a high-risk population (a population of 100,000 people with an HIV prevalence of 12%), Construct the appropriate 2 X 2 table, determine the number of false positives and false negatives, and calculate the positive predictive value of the ELISA test.

Read the following passage focusing your attention on the scientific procedures and scientific abilities illustrated in it. Think about what types of experiments (observation, testing or application) are described. Identify the hypothesis, predictions, outcomes of experiments and assumptions that appear in the passage. The standard explanation of how humans originally acquired AIDS is that HIV (human immunodeficiency virus) originally was transmitted to humans from monkeys or apes carrying SIV, simian immunodeficiency virus. How could the transmission have occurred? Several similar hypotheses involve an African hunter coming in contact with monkey blood. For example this could have occurred when a hunter butchering a monkey, got some of its blood in a cut, or when a human ate undercooked monkey meat, or when a monkey bit a human. Depending on one's assessment of the genetic diversity of HIV over time, this transmission might have occurred only a few decades ago or, alternatively, hundreds or thousands of years ago. If the latter is correct then AIDS could have been restricted to remote African villages until recent decades when trade and international travel led to the current pandemic. There are however other alternative explanations for the spread of AIDS. One of them is that AIDS arose from contaminated polio vaccines used in Africa from 1957-59. Why is this a plausible explanation? Polio vaccines are cultured on apesâ kidneys, so contamination of a batch of vaccine by an SIV is a possibility. There is a precedent: in the 1950s and early 1960s millions of doses of polio vaccine were contaminated by another simian virus, SV-40. The vaccine alleged to be the origin of AIDS was given to hundreds of thousands of people in central and west Africa from 1957-1959. These locations later had some of the world's highest levels of HIV infection. The timing is also right, since the earliest known cases of AIDS date from the 1960s; the earliest HIV-positive blood sample was collected in Kinshasa in 1959. At the time, there was no way of testing for the presence of SIVs, which were only discovered in the 1980s. Another factor adds plausibility to the theory: the vaccine was given to many infants less than a month old, in an extra high dose. Since the immune systems of infants are not fully developed, this is an excellent way to help a virus jump the species barrier. Some scientists argue that the above explanation is not necessarily correct but that it is worth taking seriously. There are a number of ways to test it. One is to analyze stocks of polio vaccine; if the explanation is correct, then it is probable that some of the vaccines will carry SIV. Another is to scrutinize records of early polio vaccination campaigns in Africa. If it is true that the immunodeficiency virus passed to humans by way of those vaccines, the areas where the campaigns took place would be the same as those where the initial sprouts of the disease occurred and where the larger number of cases occurred during the early stages of the pandemic. Another is to analyze blood samples in Africa from the 1950s and earlier (pre polio vaccination): if the immunodeficiency virus was transmitted via the polio vaccine, HIV should not be found. Adapted from âPolitical refutation of a scientific theory: the case of polio vaccines and the origin of AIDSâ. Brian Martin, published in Health Care Analysis, Vol. 6, 1998, pp. 175-179. Now reread the passage and answer the following questions.

5. For each experiment, write an outcome that would disprove the hypothesis of AIDS passing from monkeys to humans through polio vaccines.

6. What outcomes of the experiments would fail to disprove the hypothesis of AIDS passing from monkeys to humans through polio vaccines?explain.

7.What outcomes would prove the hypothesis? Hint: This is not the same as question 6. Think about what would you need to do to 100% prove a hypothesis.

8. For what reasons do scientists need to conduct testing experiments?

ochrejackal75

1.T cytoxic cells bear a receptor that is used to identify it distinctly from other immune cells. The receptor is know as cluster of differentiation CD-----------.

2. place the immunity concepts in order referencing basic immunity organization levels lines of Defense 1,2,3

A. HCL or Tears
B. Engulfing pathogens or Fever
C. Infected cell killing or immunoglobulin prosuction

3.Opsonizationot is best represented by this matching pair.

A. natural killer human cell with virus
B. Ts down regulate immune responses
C. B, cell Fc antibody class
D. neutrophils serrations marrescens
E. CD4+CXCR4 co-receptor binding and entry

4. what is the HIV protein that is involved in attachment of the virus to human immune cells?

5. identify the HIV antiviral drug that would stop the virus from exiting the helper Tcell.

isentres

retro vir

crixivan

mouse enzyme

selzentry

6. The maim type of immune cell infected by HIV are the -----------cells in the course of an infection.

7.All of the following are physical barriers to pathogens except

unbroken skin

mucous

hairs

tears

t cellso

8. B cells are activated by?

9. plasma cell best description?

function in cell mediated immunity

are derived from T lymphocytes

produce and secrete antibodies

responsible for making complement protein

10. when does the lectin pathway for the complement systems achieved it's goal

1. it begins with antibodies similar to the classical pathway

2. the goal happen during a lost of function

3. once C3 breaks a part the 3 goalso of the complement system begin

4. when complement protein B,D and P , are attracted to the pathogen

MICR 2420 Lecture 23: MICR 2420 Lecture 23

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