MICR 3230 Lecture Notes - Lecture 6: Master Of Veterinary Science, List Of Breaking Bad And Better Call Saul Characters, Signal Transduction

• School: University of Guelph
• Department: Microbiology
• Course: MICR 3230
• Professor: Kaushik/ Mallard

Document Summary

B cell antigen receptors, signaling and antigen-antibody interactions. Either ionic bond, hydrogen bond, hydrophobic interactions, or van der waal interactions. Signal transduction that initiates after binding of ligand to its receptor. To allow signal transduction from the ligand to the cell bearing the receptor a high affinity receptor-ligand interaction is required via een ding ngth of ive ope. High affinity is important because each individual interaction is weak, so having enough interactions are important so they have enough time together and are close enough together for signal transduction to occur. This requires many noncovalent interactions, considering each individual interaction is weak. It also requires a very close fit (or degree of complementarity) between the receptor and the ligand. The binding reaction of a receptor (r) and a ligand (l):r + l rl. The association constant (ka) = [rl] / [r] [l] Ka is a measure of the affinity of the receptor-ligand pair.