MICR 3330 Lecture Notes - Lecture 7: Closteroviridae, Filoviridae, Cowpox

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amaranthweasel562

27 Jun 2018

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Discovery, Morphology, Composition and Architecture of Viruses

Discovery of First Virus: Mayer

1879: Extract from tobacco with mosaic symptoms was infections

1882: preliminary report – soluble, enzyme-life contagium

1886: Publication- an unknown bacterium

Discovery of TMV:

Ivanovsky

thru bacterium-proof chamberland filter; filtrate passed thru and was still infectious

reported to academy pf science that the filter must be defective

Beijerinck

pass filter  dilute filtrate  inoculation  replenish

contagium vivum fluidum (contagious living fluid)

lesson: when you find something strange don’t disregard it

Stanley

crystallization of TMV

virus is protein in nature

Bawden & Pirie

TMV viron contains 5% RNA

Ruska

First EM graph of TMV

Proof of RNA as Genetic Material: Fraenkel- Conrat

CP alone assembles into virion  not infectious

CP and RNA assembles into viron  infectious

RNA alone  infectious

Conclusion: RNA and not protein is the genetic material

The Frist Animal Virus: Loeffler & Frosch

Filterable virus from cattle infected with foot- and-mouth-disease

Most feared contagious viral disease of cloven-hoofed animals

Reduction in milk, meat and infertility in females

The First Human Virus: Finlay & Reed

Yellow fever virus (1901)

Devastating disease in tropics and subtropics

Infects monkeys and mosquitos introduced thru slave trade

Transmission by insect vector (Finlay)

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Document Summary

1879: extract from tobacco with mosaic symptoms was infections. Ivanovsky thru bacterium-proof chamberland filter; filtrate passed thru and was still infectious reported to academy pf science that the filter must be defective. Beijerinck pass filter dilute filtrate inoculation replenish contagium vivum fluidum (contagious living fluid) lesson: when you find something strange don"t disregard it. Stanley crystallization of tmv virus is protein in nature. Proof of rna as genetic material: fraenkel- conrat. Cp alone assembles into virion not infectious. Cp and rna assembles into viron infectious. Conclusion: rna and not protein is the genetic material. Filterable virus from cattle infected with foot- and-mouth-disease. Most feared contagious viral disease of cloven-hoofed animals. Reduction in milk, meat and infertility in females. Infects monkeys and mosquitos introduced thru slave trade. Twort: attempt to culture vaccina; contamination, glassy transformation something is eating at bacteria producing a glossy appearance.

MICR 3330 Lecture Notes - Lecture 7: Closteroviridae, Filoviridae, Cowpox

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