MICR 3230 Lecture Notes - Lecture 2: Hematopoietic Stem Cell, Cfu-Gemm, Bone Marrow
30 Nov 2017
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Document Summary
Immune responses result from coordinated activities of many cells, organs, and microenvironments in the body. Hematopoietic stem cells (hscs) have the ability to differentiate into many types of blood cells. All red and white blood cells develop from a pluripotent hsc during hematopoiesis. Hsc divides, creating one cell the exact same as it is (self-renewal, so that they always exist) and one cell that becomes a progenitor for something else. Hematopoiesis in humans begins in embryonic yolk sac during first weeks of development followed by migration of pluripotent hematopoietic stem cells to fetal liver in the 3rd month of gestation. At 7-month of gestation and after that, hematopoiesis mainly occurs in bone marrow. Myeloid progenitors (giving rise to dendritic cell, macrophage, neutrophil, eosinophil, basophil, erythrocyte and platelets) Lymphoid progenitors (giving rise to t and b cell, natural killer [nk] cell and dendritic cell)
