MICR 3330 Lecture Notes - Lecture 6: Infectious Salmon Anemia Virus, Thogotovirus, Influenzavirus B
3 Feb 2018
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Document Summary
Influenza viruses: a group of truly unique and important viruses. Belie(cid:448)ed to (cid:271)e due to (cid:862)astrologi(cid:272)al influen(cid:272)es(cid:863) Periodic pandemics (1890, 1918, 1957, 1968, 1977, 2009) Since 2010 there have been 140,000 710,000 hospitalizations and 12,000 56,000. Isolation introduced by w. smith, sir andrews, sir laidlaw at mrc britain in 1933. Infection in upper and lower respiratory tract deaths per year. Burden on health care system; billion per annum. Young, old, and immune compromised are most vulnerable. Very painful and even infects the strong and prime. Broad host range (humans, birds, swine, horses, etc. ) Genus thogotovirus: thogoto virus (thov) (influenza d virus) Within the so called nucleocapsids you have rna, np, and the tripartite polymerase enzyme (pa, pb1, pb2) Influenza viruses must enter the nucleus to complete replication. Pa contains endonuclease activity, cleaves capped host mrna. Synthesizes viral mrna using oligonucleotides from host mrna.
