NUTR 3210 Lecture Notes - Lecture 12: Atkins Diet, Tuber, Zone Diet

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Pepsin (endopeptidase) active form of pepsinogen. Produces pancreatic juice that contains zymogens (digestive proenzymes) Hcl secreted from parietal cells; triggered by gastrin, acetylcholine, histamine, etc. Zymogen active enzyme (using proteolytic cleavage) Released in stomach as pepsinogen (inactive zymogen) Creates large polypeptides, oligopeptides, and free aas. Activation takes place in a series: activation of trypsinogen to trypsin in small intestine (happens with enteropeptidase present from the small intestinal cells not in pancreas, trypsin activates all of the other active enzymes present. Some enzymes that are responsible for breakdown are coming small intestinal cells and some come from pancreas. Endopeptidases clip inside the peptide (act within the peptide chain) and exopeptidases clip outside. Most aa absorbed in proximal small intestine (pept1 = peptide transporter 1) Free aas have no absorptive advantage (i. e. protein supplements) Amino acids participate in secondary transport by following sodium favourable concentration gradient. Aas are either transported out of the intestinal cell, or used within the enterocyte for:

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