NUTR 3210 Lecture Notes - Lecture 17: Vitamin K Epoxide Reductase, Vitamin D Deficiency, Rheumatoid Arthritis
19 Mar 2017
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Document Summary
In basis, bones start as collagen and gradually become infused with mineral. 60/40 ratio begins to drop 50/50 40/60 with deficiency. Bones do not mineralize properly and can"t support the body"s weight when they start walking (permanent outcome) Was seen in britain during industrial revolution: adolescents to adults osteomalacia. Bones become demineralized (can be reversed with supplementation) Fractures can occur easily: middle aged to elderly osteoporosis. Normal part of aging (loss of bone mineral and organic parts of bone) Seasonal variation: suggests that were losing 25-ohvitd in blood, using to produce other things, through supplementation, it can be preserved in the bloodstream (vitamin d levels are affected by change in season) Recent changes to the rdi to vitamin d: the rda for vitamin d intake for adults = 600 iu. So this would mean 15ug of vitamin d/day: rda recently increased (nov 2010) tripled! Vitamin d toxicity: no risk of vitamin d toxicity from sun exposure.
