NUTR 3210 Lecture Notes - Lecture 11: Acetyl-Coa, Cyclic Adp-Ribose, Schiff Base
2 Apr 2017
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Document Summary
Introduction to niacin: water soluble vitamin discovered through condition pellagra in humans and a similar condition called black tongue in dogs due to this relationship; niacin was sometimes referred to as a anti black tongue factor. Niacin as enzyme cofactor as nad and nadp, niacin functions as an important enzyme cofactor in many biological reactions the conversion of different forms of niacin to the various cofactor forms (includingnad+, nadh, 1. nicotinic acid (plant provitamin) and tryptophan are converted to nicotinamide in vivo during their incorporation into the pyridine nucleotides nad+. Nad+ can then be phosphorylated on the ribose closest to the adenine, producing nadp+. These are the biologically active forms of niacin, which function as soluble cofactors in over. 2. the nad+ formed in step 1 is used by hundreds of enzymes to oxidize other substrates. Two electrons (and one proton) are removed from the substrate and passed to nad+, forming nadh. Nad+ is acting as an oxidizing agent in these reactions.
