NUTR 3210 Lecture Notes - Lecture 8: Ketogenic Amino Acid, Glutamate Dehydrogenase, Oxidative Deamination

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Glucogenic amino acids can be used to produce energy, glucose, glycogen, and lipids, while ketogenic amino acids can be used to produce energy and lipids. Note: although glucogenic amino acids can be used to produce lipid, they rarely are. The free nh3 can be added to another glutamate molecule to form glutamine by the action of the enzyme glutamine synthase. Glutamine is then ready to move to the liver or kidney, carrying nh3 for excretion. *following amino acid catabolism, glutamate will also be transaminated to alpha-kg, and the nh3 removed is transferred to pyruvate to form alanine. This reaction is catalyzed by glutamate pyruvate transaminase. The alpha-kg can be used to produce energy, etc, although under these conditions, the alpha- Kg will likely cycle back and get another nh3 in a transamination reaction. Alanine is then ready to move to the liver, carrying nh3 for excretion.

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