NUTR 3360 Lecture Notes - Lecture 10: Valine, Proopiomelanocortin, Attention Deficit Hyperactivity Disorder
30 Sep 2016
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Leptin is secreted from adipose tissue, therefore the more adipose tissue you have, there more leptin there is. Leptin is an anorexogenic, so one would think that obese people have supressed appetites. This is not the case though, because obese people become leptin resistant. Treatment: daily subcutaneous injections of recombinant human leptin. Reverses immune system defects and infection risk. Improves thyroid function and allows for appropriate development of puberty. ** this treatment does not help obese individuals because they already have leptin; they are just leptin resistant. What other mechanisms may jeopardize leptin function: a mutated leptin receptor. Leptin receptor (lepr) mutations: 6 isoforms of lepr exist in humans due to differential splicing, the long form (leprb) is expressed in hypothalamic neurons, only leprb has the intracellular domains necessary to activate the. Jak/stat signalling pathways, which are essential to transduce leptin function: lepr mutation = complete or partial loss of receptor signalling, despite normal leptin levels.
