NUTR 3360 Lecture Notes - Lecture 4: Starch, Interleukin 15, Uncoupling Protein
17 Sep 2016
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Document Summary
The importance of studying dna: understand individual variability with regards to disease phenotype, but also response to interventions. Who to target with what: determine influence of gene expression and function. Structural variation in the genome: determine genes underlying common diseases. Identify new genetic targets for pharma/nutraceuticals: understand how disease is passed from one generation to the next. Heteromorphisms: visible region of a chromosome that varies in size or morphology. Junk dna: non-coding dna regulates protein coding though: non-coding functional rna (trna, rrna, sirna, promoter and repressor sequences, sequence recognition during meiosis, 80% of junk dna is actually active. Segmental duplications: also called low copy repeats , consists of regions of dna that occur in 2 or more copies per haploid genome. Constitutes about 5% of the human genome: spread out over an individuals entire genome, not random within the genome, segmental duplications can be copy number variance (cnv)
