NUTR 4320 Lecture Notes - Lecture 15: Lamina Propria, Gut Flora, Tight Junction
3 Apr 2019
School
Department
Course
Professor
Document Summary
Host anti-bacterial defence system: protection from the gut microbiota, intact bact ria, portion of a bacteria that has been lysed (eg. pgn; lps, microbial derived metabolites (thousands possible -> metabolome, 1. Epithelial barrier: single cell barrier between the microbiota and all host tissues: critical importance of tight junctions and adherent junctions, dont want them overruling and running that space, 2. Mucus barrier: mucus protection - secreted by goblet cells and covers the epithelial barrier: substance to keep some bacteria away, 3. Anti-bacterial or anti-microbial proteins: * without these defence mechanisms bacteria translocate/cross epithelial barrier and enter host tissues. Stem cells: haven"t differentiated yet - used to form all cell types that make up epithelial cell barrier. Will start to differentiate and move up and become another cell type (epithelial, goblet, enteroendocrine* link with upcoming obesity notes) Reach top of crypt and after 2-3 days start apoptosis -> broken up in lumen -> lose in feces.
